Summary-Outbreaks of Unexplained Neurologic Illness-Muzaffarpur, India,2013-2014
Muzaffarpur,India has continually reported seasonal outbreaks of acuteneurologic, which is hard to explain, since 1995. This illnessaffects young children and has a strong association with high casefatality. Several proposals on multiple potential etiologies, likepesticide exposure and infectious encephalitis, have been forwardedhowever, these proposals have not been assessed in a systematicmanner. The article ‘Outbreaksof Unexplained Neurologic Illness-Muzaffarpur, India, 2013-2014’plays a key role in classifying the aforementioned illness as anoninflammatory encephalopathy. The classification is supported byboth laboratory and clinical findings these findings includenegative diagnostic results for various pathogens that are commoncause of infectious encephalitis in Muzaffarpur.
Itshows that about 60 percent of individuals affected by the illnesshad low blood glucose (less than 70 mg per dl) during the admissionprocess. The low level of blood glucose was associated with pooreroutcomes this attracted recommendations for rapid assessment as wellas for treatment of low blood glucose. The low level of blood glucosetriggered a high likelihood that an individual exposed to a toxinwould easily experience encephalopathy, seizures, and low bloodglucose. The article hypothesize that exposure to MCPG could easilylead to acute hypoglycemia as well as encephalopathy in some infants.
Thearticle further highlights some ongoing laboratory investigationsthat aim at assessing and understanding why some children suffer fromthe illness. Similarly, analysis of epidemiologic data, which wascollected in the 2014 case-control study, is highly recommended sinceit has a high possibility of elucidating potential risk factors forillness among these children. Such case control study incorporateswell researched and detailed histories with regard to exposure topesticides or consumption of litchis.